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sábado, 5 de febrero de 2011

Tratamiento crónico de melatonina: Efecto en la neurogenesis

 Sobre el buen dormir y la melatonina:

Chronic treatment with melatonin stimulates dendrite maturation and complexity in adult hippocampal neurogenesis of mice

J. Pineal Res. 2011; 50:29–37
Gerardo Ramirez-Rodriguez, Leonardo Ortíz-López, Aline Domínguez-Alonso, Gloria A. Benítez-King and Gerd Kempermann

1Laboratory of Neurogenesis, Department of Neuropharmacology, National Institute of  Psychiatry. Mexico D.F., Mexico; 2Department of Neuropharmacology, National Institute of Psychiatry, Mexico D.F., Mexico; 3CRTD –Center for Regenerative Therapies Dresden,
Dresden, Germany

Fig. 6. Schematic representation of melatonin effects altering dendrite complexity of new neurons. Chronic melatonin treatment (8 mg/kg) for 14 days increases dendrite complexity of new neurons identified by doublecortin staining (imagen de abajo) , while in mice treated with vehicle the number of immature neurons and neurons with more complex dendrites are lower than that in melatonin-treated mice (imagen de arriba). Draw box shows the events corresponding to the cell survival and dendrite maturation of the neurogenic process in which melatonin plays a role.

Abstract: In the course of adult hippocampal neurogenesis, the postmitotic maturation and survival phase is associated with dendrite maturation. Melatonin modulates the survival of new neurons with relative specificityDuring this phase, the new neurons express microtubule-associated protein doublecortin (DCX). Here, we show that the entire population of cells expressing DCX is increased after 14 days of treatment with melatonin. As melatonin also affects microtubule polymerization which is important for neuritogenesis and dendritogenesis, we studied the consequences of chronic melatonin administration on dendrite maturation of DCX-positive cells. Treatment with melatonin increased the number of DCX-positive immature neurons with more complex dendrites. Sholl analysis revealed that melatonin treatment lead to greater complexity of the dendritic tree. In addition, melatonin increased the total volume of the granular cell layer. Besides its survival-promoting effect, melatonin thus also increases dendritic maturation in adult neurogenesis. This might open the opportunity of using melatonin as an adjuvant in attempts to extrinsically stimulate adult hippocampal neurogenesis in neuropsychiatric disease, dementia or cognitive ageing.

Saludos cordiales/Gustavo

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